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Sustained release of spray-dried combination

2011-9-23  dried combination powders showing the sustained release of two chemically distinct therapeutic agents. Spray dried formulations were produce

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Sustained Release of Spray-Dried Combination Dry

2016-7-13  The aim of this work is to use leucine-HPMC combination as an excipient to impart sustained release profiles to drugs. The influence of leucine-HPMC combination as an

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Academic Sciences Asian Journal of Pharmaceutical and

The aim of this work is to use leucine- HPMC combination as an excipient to impart sustained release profiles to drugs. The influence of leucine-HPMC combination as an excipient on spray

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Sustained Release of Spray-Dried Combination Dry

2019-5-30  Sustained Release of Spray-Dried Combination Dry Powder Inhaler Formulation for Pulmonary Delivery Description The controlled release of drugs for pulmonary delivery is a

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Sustained release of diltiazem HCl tableted after co-spray

Co-spray dried products with PVP content lower than in physical mixtures result in slower release, while at equal PVP content (19 and 29% w/w of excipient) in similar release (f2 > 50). Increase

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Sustained release of etanidazole from spray dried

2002-6-17  The spray drying process consists of converting liquid into powder by spraying a solution or a liquid dispersion through an atomization nozzle into hot air. The solvent

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Sustained delivery by leucine-modified chitosan spray

The controlled co-delivery of hydrophilic and hydrophobic entities underlines the capability of spray drying to produce respirable particles with sustained release for delivery to the lung.

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Preparation of sustained release capsules by electrostatic

2018-5-30  Preparation of sustained release capsules by electrostatic dry powder coating, using traditional dip coating as reference Abstract Lately, a great deal of attention is being paid to

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Preparation and characterization of sustained release

2020-10-19  Pirfenidone (PFD) is a drug of choice for the treatment of idiopathic pulmonary fibrosis. For the preparation of sustained release microparticles of PFD, Ethyl cellulose (EC

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Sustained delivery by leucine-modified chitosan spray

Spray drying (SD) has been increasingly used for manufacturing inhalable powders [23]. It is a one-step process by which a liquid feed is converted into dry particles via three fundamental...

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Sustained release of etanidazole from spray dried

2002-6-17  Particle size of microspheres fabricated using EA is also slightly larger than those prepared by DCM (Table 1, Table 2) irrespective of the combination ratios of DCM–EA and the drug loadings used.The increase of the particle size is probably owned to the comparatively higher kinematic viscosity .A significant amount of work has been devoted to the investigation

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Sustained release of insulin from sodium hyaluronate

2003-9-4  Sustained release of insulin from sodium hyaluronate based dry powder formulations after pulmonary delivery to beagle dogs Abstract Hyaluronic acid (HA) and recombinant human insulin were co-spray dried to form a dry powder suitable for inhalation (Mass Median Aerodynamic Diameter, MMAD=1 to 4 microm).

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Formulation and Optimisation of Sustained Release Spray

2013-3-1  Multilayered particles are emerging, powerful pharmaceutical platform for targeted, triggered and sustained drug delivery, exhibiting several advantages over single-layered particles (Saha Loo...

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Formulation and optimisation of sustained release spray

The objective of this study was to investigate the combined influence of three independent variables in the preparation of glipizide microspheres by the spray-drying method. A three factor, three level Box-Behnken design was used to derive polynomial equations and construct response surface plots to predict responses.

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SUSTAINED RELEASE DRUG DELIVERY SYSTEM :

2012-9-24  Disadvantages of sustained release dosage forms1, 2, 3 1) Probability of dose dumping. 2) Reduced potential for dose adjustment. 3) Cost of single unit higher than conventional dosage forms. 4) Increase potential for

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A REVIEW ON: SUSTAINED RELEASE TECHNOLOGY

2019-2-9  Classification of Oral Sustained or Controlled Release Systems The controlled release systems for oral use are mostly solids and based on dissolution, diffusion or a combination of both mechanisms in the control of release rate of drug. Depending upon the manner of drug release, these systems are classified as follows: 1.

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Preparation and characterization of sustained release

2020-10-19  Pirfenidone (PFD) is a drug of choice for the treatment of idiopathic pulmonary fibrosis. For the preparation of sustained release microparticles of PFD, Ethyl cellulose (EC 300) with Eudragit RS...

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REVIEW: SUSTAINED RELEASE DOSAGE FORMS

2013-4-7  A dose size of 500-1000mg is considered maximal for a conventional dosage form. This also holds true for sustain release dosage forms. Since dose size consideration serves to be a parameter for the safety involved in

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A triple combination 'nano' dry powder inhaler for

2021-5-26  The dried powders were finally developed into the combination DPI by physically mixing the spray-dried powders with lactose blends, i.e., various ratios of inhalation grade lactose, Lactohale 100 and Lactohale 300, to further enhance the flow properties and aerosolization of

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Controlled release of caffeine from tablets of spray-dried

2019-3-1  Operating conditions for spray drying included a main air flow rate of 38 m 3 /h (aspirator setting of 100%), a pump rate of 8 mL/min (25% of the maximum rate) and a nozzle air flow rate of 540 L/h (45 on the nozzle rotameter scale). The inlet temperature was changed from 100 to 190 °C to find the optimal temperature.

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Sustained release of etanidazole from spray dried

2002-6-17  The main reasons for the failure are attributed to the high solubility of etanidazole in aqueous solution and the lower particle size (1–2 μm) obtained via the spray drying technique. Other factors such as the solvent and polymer type used may also contribute to

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Sustained release of a model water-soluble compound via

The two solutions were mixed together, and the solution was spray dried to produce MP. MP were characterized for morphology, size, release kinetics, aerosol dispersion, and cellular interactions. Results: Ac-Dex MP exhibited corrugated morphology and aerodynamic diameters from 2.06 to

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Sustained release of insulin from sodium hyaluronate

2003-9-4  Formulation of spray drying feedstocks Insulin (0.1 g) was dissolved in hydrochloric acid (0.05 M, 1.4 ml). Sodium hydroxide (1 M, 0.09 ml) was added dropwise to the solution, until the initially precipitated insulin had redissolved. The insulin solution was then diluted with 106.8 ml water (99.3 ml for Zn 2+ containing solutions).

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Sustained-Release, Extended-Release, and Other Time

Sustained-release dosing is also associated with relatively uniform blood levels of the drug across the course of the day; peaks and troughs in blood levels, noticeable with immediate-release dosing, are diminished. The advantage of blunted peaks is that the risk of adverse effects, associated with the peaks, is diminished.

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Microparticles for sustained release of water-soluble drug

Controlled release microparticles in a sub-gram-scale batch were fabricated using a ball mill, dry coating technique, to coat the water-soluble core material. This process also guaranteed the maintenance of the containment's integrity during the dry coating process. Quinine (average diameter, ca. 10

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Combination of irreversible electroporation with sustained

2021-5-24  Subsequently a sustained release of over 20% of coated PAHM continued over the course of 1 week (between days 2 and 7). Figure 5 Release kinetics of PAHM from coated embolic microspheres in cell ...

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Sustained-release, extended-release, and other time

A disadvantage of time-release formulations is that they may be incompletely absorbed; this is a serious issue in patients with acute or chronic intestinal hurry disorders, such as gastroenteritis or irritable bowel syndrome. Time-release formulations may also be more expensive than immediate-release formulations.

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Preparation and characterization of sustained release

2020-10-19  Pirfenidone (PFD) is a drug of choice for the treatment of idiopathic pulmonary fibrosis. For the preparation of sustained release microparticles of PFD, Ethyl cellulose (EC 300) with Eudragit RS...

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A REVIEW ON: SUSTAINED RELEASE TECHNOLOGY

2019-2-9  The controlled release systems for oral use are mostly solids and based on dissolution, diffusion or a combination of both mechanisms in the control of release rate of drug. Depending upon the manner of drug release, these systems are classified as follows: Continuous release systems Delayed transit and continuous release systems

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Actively separated microneedle patch for sustained

2022-4-29  All the patches shown burst release at 2 h, and the burst release decreased with the increase of β-sheet content, from 50% to 20%, similar results were found in work by Gong et al 59. The burst release at 2 h may attribute to the uniform distribution of rhGH and silk protein, the rhGH embedded on the surface of the MN patch was released quickly.

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